Amferia Antimicrobial Hydrogel Wound Dressing
First Look into the Technology
Technology in Brief
Amferia’s proprietary patented technology is a new and effective antibacterial material. The material consists of bioinspired and amphiphilic antibacterial polymers that target and rapidly kill bacteria upon contact, including numerous strains of antibiotic resistant bacteria like MRSA and MDR E. Coli.
The material is highly selective and targets only bacteria while being entirely non-toxic to human cells. We have today transformed this concept into a first prototype of a preventive wound care patch. Our goal is to develop and bring this concept into the market as a preventive care for patients at risk of acquiring dangerous skin infections.
Science behind Amferia
Amferia’s technology is born out of years of research performed at Chalmers University of Technology. In brief, the scientific concept behind Amferia’s antibacterial technology is based on a new material known as amphiphilic antimicrobial hydrogels. An amphiphilic hydrogel is a soft material with more than 70% water and displays both hydrophilic and hydrophobic character. The surface of amphiphilic hydrogel consists of antimicrobial peptides (AMPs) that are permanently (or covalently) bound to the hydrogels amphiphilic structure. AMPs interact with the bacteria and when in contact, disrupts the bacterial cell wall rapidly. Effectively killing the bacteria.
The AMP-hydrogel has proven to not release any substances into the environement, effectively making it a singular material that can be formed into a desired antimicrobial medical device such as soft wound care patches or as durable functional devices such as catheters.
Antimicrobial analysis of confirmed >99% killing efficiency against multiple gram-negative and gram-positive bacterial strains including MRSA, MDR E. Coli and Pseudomonas aeruginosa. It has also been proven to be non-toxic to mammalian cells. A prototype of a wound plaster has been developed with easy applicability and functionality. Image shows schematic drawing of the covalently attached AMP molecules to the hydrogel surface.
The foundations of Amferia’s technology are described in the following scientific papers
More information on scientific data and publications will be updated in this space soon.
Can’t wait?! Get in touch with us to know our technology in more detail.
Today, we are translating the technology into functional products to the clinic. Our present work focusses on utilising the technology as patches, sprays, granules for wound care and extending to coatings on medical device surfaces.
What is antibiotic resistance?
Antibiotic resistance (ABR) happens when bacteria develops resistance against our antibiotics. This makes simple infections such as skin wound infections lethal. Today, we are in a situation where many types of bacteria has evolved to an extent where, none of our antibiotics work against them. The world health organization estimates ABR to become a leading cause of heathcare threat to humanity by 2050.
A common antibiotic resistant bacteria is MRSA or Methicillin Resistant Staph. Aureus. MRSA is a dangerous bacteria that can cause skin infections with life-threatening complications. MRSA is only one of the many strains of bacteria that is resistant to antibiotics today.
Antibiotic resistant infections, especially skin infections is a threat to human existence today. This has called for a need for new solutions and new pathways to ensure a sustainable future. At Amferia we believe we can join the fight against antibiotic resistance through a new technology that we have developed for the cause. We envision a healthy and safe future for humanity.
What you can do
Antibiotic resistance happens when bacteria change and become resistant to the antibiotics used to treat the infections they cause.
- Only use antibiotics when prescribed by a certified health professional.
- Always take the full prescription, even if you feel better.
- Never use left over antibiotics.
- Never share antibiotics with others.
- Prevent infections by regulary washing your hands, avoiding contact with sick people and keeping your vaccinations up to date.